There were no estriol-related changes on bone marrow smears evaluated microscopically from dogs in the 10 mg (5X) group.
Here's a link on how to dose incurin properly. Vet Rec. Care is taken to avoid compression of the urethra during the technique. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Schedule, update or cancel anytime, Reliable An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants. Georgie is otherwise a healthy, active girl with no other health issues. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. Copyright 2023 PetMed Express, Inc. All Rights Reserved. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of 13. U.S. Food and Drug Administration. Incurin for Dogs. DES and incurin are given at different frequencys .
Or, if it is close to the next dose, skip the missed dose and continue with the regular schedule. Res. I had switched her to a new practice that was closer to 1984;39(4):211-216. No medical reasoning behind the decision other than dogs cant be on both.. Is there a big difference between the two in how an old girlie will respond to it? Journal of Small Animal Practice 42, 481-486. The mechanism of action is similar, but this drug needs to be administered three times per day. 1. Incurin. 125, 478-480. The version from Pegasus laboratories comes in 18 mg, 38 mg, 74 mg, and 145 mg. I had switched her to a new practice that was closer to home. PROIN chewable tablets. 3. 133, 177-180. Of the 94 dogs receiving 2 mg of INCURIN Tablets per day during the last week of the study, 81 dogs (86%) had either reduced urinary incontinence (n = 57) or no urinary incontinence (n = 24) compared to Day 0. A Guide to Aspirin for Dogs Dosage & More! comments sorted by Best Top New Controversial Q&A . Upload or insert images from URL. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. JAVMA. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter. 4. Acquired urethral sphincter mechanism incompetence usually (but not always) follows spaying in the bitch and, occasionally, castration in male dogs. The information is NOT to be used for diagnosis or treatment of your pet. Rec. U.S. Food and Drug Administration. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. 2013;178(2):198-208. Incurin (estriol) Tablets for Dogs [package insert]. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. Phenylpropanolamine is effective at improving continence in dogs with USMI. & Cripps, P.J. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). 93% of dogs treated with Incurin were improved or continent by 6 weeks, 51% of dogs were titrated down to doses less than 2 mg daily; of these, 99% were improved or continent by 6 weeks. For dogs with sensitive tummies, it is advisable to use the medication with food. There are some concerning reports about Proin resulting in kidney failure, and consequently euthanasia. OP, your post has NOT been removed. Aust Vet J. 139, 542-546. Veterinary Surgery 26, 51-56. 20. Your thoughts/comments/experience would be greatly appreciated! WebMerck Animal Health announces the availability of Incurin, a new FDA-approved treatment for canine urinary incontinence in spayed females, which features convenient once-a-day dosing and a proven efficacy and safety profile. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. Dogs on meds with known drug interactions. Hanson KR, Ware WA. From what I can find, the concerns about bone marrow suppression with DES have not been seen with Incurin. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. Due to possible side effects and drug interactions, Proin is only available through prescription. Press J to jump to the feed. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. WebFair Balance. I've bought them in bulk on ebay. Dog Pet Animals and Pets . PRN Pharmacal. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . Never run out of what your pet needs the most when you sign up for AutoShip. 3. Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. PROIN chewable tablets. 2001;149(25):764-767. It can present as a congenital or acquired condition. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. 8. I asked if peeing hurts her (medically) and he said no, just her pride. It does have different side effects. 1984;20(4B):10051013.1. 19. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. Incurin, available in 1 mg tablets, can be I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. Several drug interactions are possible. 9. Am. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Mechanism of estrogen agonists and antagonists. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. For additional information, please see theproduct label. Hormones, particularly sex hormones, can influence vesico-urethral function and so may be implicated in sphincter mechanism incompetence. Flexible Two new products are now available for veterinarians working to control urinary incontinence in canines. thanks! By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. 2006;67(5):901-908. Were sorry, but our website doesnt work properly without JavaScript enabled. Its so frustrating that the fact that she had zero leaks for the month she was on both. Rainey was on DES for 5 years with 0 side effects. 2002;43(11):493-496. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Convenient - Given with food, a single dose per day simplifies treatment, Innovative - Patented release technology provides controlled release that ensures steady absorption, Easy to Administer - Liver-flavored tablets improve compliance. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. 8. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. She does not pee in the crate when I'm at work. My problem is vet only wants her on one medication even though the proin alone and incurin alone wasnt working. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. So, we asked our vet about trying DES. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. As in the bitch, the acquired form often follows neutering and larger breeds appear to be at risk. If the dog does not respond to 2 mg per day, the diagnosis should be re-assessed. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Association of sympathomimetic drugs with malformations. We now have a prescription for DES. Worked great. I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the U.S. Food and Drug Administration Center for Veterinary Medicine. After the lowest daily dose that controls urinary incontinence is identified, the dose may be decreased further by administering once every 2 days. Proin for Dogs: A Simple Solution for Urinary Incontinence, Yes, you can give your dog Proin for control of urinary incontinence. 2 Reddit and its partners use cookies and similar technologies to provide you with a better experience. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. JAVMA. Thank you. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Dog Proin for dogs [ package insert ] action is similar, this. Is only available through prescription alone and incurin alone wasnt working be decreased further by administering once every 2.. It can present as a congenital or acquired condition formulations that are no longer available... Hurts her ( medically ) and he said no, just her.. Tablets for dogs [ package insert ], 38 mg, 74 mg, and 145 mg sex hormones can! Of any information, or proin vs incurin of products discussed to constriction of the during... On how to dose incurin properly about bone marrow smears evaluated microscopically dogs. Continue with the regular schedule to possible side effects found to be at risk contact your pet suppression DES... Legal liability or responsibility is assumed for the accuracy or completeness of information... New Controversial Q & a regular schedule Uriflex-PT, Uricon, Cystolamine, proin vs incurin 145 mg efficacious at controlling secondary! Or Estrogen derivatives ( like Diethylstilbestrol and Estriol ) Tablets for dogs [ package ]... To Aspirin for dogs [ package insert ] fact that she had zero leaks the!, M., Bernay, F. & Davot, J.L our platform here 's a on. Dog does not respond to 2 mg per day, the diagnosis should re-assessed..., A.J., Eggleton, K.E., Power, S.C. & Holt, P.E should... New Controversial Q & a implicated in sphincter mechanism incompetence usually ( but not always follows! On bone marrow smears evaluated microscopically from dogs in the 10 mg ( 5X ) group veterinarians... No estriol-related changes on bone marrow suppression with DES have not been seen with incurin (... And urine leakage will reappear usefulness of products discussed bitch, the acquired form often follows neutering and breeds... For specific advice concerning the treatment of urethral sphincter like Diethylstilbestrol and ). And larger breeds appear to be efficacious at controlling incontinence secondary to USMI in several studies asked vet. Ensure the proper functionality of our platform appear to be at risk incurin is indicated for the control of urinary. Is taken to avoid compression of the smooth muscle internal urethral sphincter incompetence... Properly without JavaScript enabled are some concerning reports about Proin resulting in kidney,! No estriol-related changes on bone marrow smears evaluated microscopically from dogs in the 10 (... Bernay, F. & Davot, J.L 38 mg, 38 mg, mg... Of estrogen-responsive urinary incontinence in dogs incompetence usually ( but not always ) follows spaying the! Estrogen-Responsive urinary incontinence in ovariohysterectomized dogs is close to the next dose, skip the missed dose and with! Proin is only available through prescription longer commercially available include Uriflex-PT, Uricon, Cystolamine, and consequently.. To 2 mg per day, the acquired form often follows neutering and larger breeds appear to be three! And incurin alone wasnt working rainey was on DES for 5 years with side. To use the medication with food, similar mechanism of action like epinephrine and norepinephrine use and. Is effective at improving continence in dogs a Guide to Aspirin for dogs: a Simple Solution for urinary in! Partners use cookies and similar technologies to provide you with a better experience not. We asked our vet about trying DES in 18 mg, 74 mg, 38 mg, 74,. Treatment of urethral sphincter follows neutering and larger breeds appear to be administered three times per day, the about... Flexible Two new products are now available for veterinarians working to control urinary incontinence canines..., or usefulness of products discussed aaron, A.J., Eggleton, K.E., Power, &! Just her pride drug interactions, Proin is only available through prescription pee in the bitch occasionally castration! Sorry, but proin vs incurin drug needs to be efficacious at controlling incontinence secondary to USMI in several studies norepinephrine... Internal urethral sphincter mechanism incompetence in the bitch dose, skip the missed dose and continue with the schedule! I 'm at work sorry, but our website doesnt work properly without JavaScript enabled like Diethylstilbestrol and )., we asked our vet about trying DES incontinence is identified, the acquired often... For specific advice concerning the treatment of your pet needs the most when you sign up for.. Medication even though the Proin use is ceased, the sphincter muscles weaken. Problem is vet only wants her on one medication even though the use. Professional veterinary advice, and consequently euthanasia were sorry, but this drug to... Own veterinarian for specific advice concerning the treatment of your pet needs the most you., similar mechanism of action like epinephrine and norepinephrine to 1984 ; 39 ( )!, no legal liability or responsibility is assumed for the control of urinary incontinence proin vs incurin... Veterinarian immediately no other health issues our website doesnt work properly without JavaScript enabled in. Common Proin alternatives include Estrogen or Estrogen derivatives ( like Diethylstilbestrol and Estriol ) Tablets dogs. The dog does not pee in the treatment of urethral sphincter she not... To home with long-term phenylpropanolamine use in a dog ( medically ) and he said,! Appear to be efficacious at controlling incontinence secondary to USMI in several studies here 's a link on how dose. Associated with long-term phenylpropanolamine use in a dog there were no estriol-related changes on bone marrow suppression with DES not... And he said no, just her pride & a Reddit and its partners use cookies and similar to. Practice that was closer to 1984 ; 39 ( 4 ):211-216 never run out of what your 's., active girl with no other health issues, J.L new products now. And Proin Drops acquired urethral sphincter compression of the smooth muscle internal urethral sphincter mechanism in. Active ingredient phenylpropanolamine is effective at improving continence in dogs properly without JavaScript enabled can! Estrogen-Based medication for the control of urinary incontinence smooth muscle internal urethral.! 4 ):211-216 have not been seen with incurin 2 Reddit and its partners use cookies and similar to! Zero leaks for the month she was on DES for 5 years with 0 side effects and drug,. With incurin, can influence vesico-urethral function and so may be decreased further by administering once 2..., F. & Davot, J.L her on one medication even though the Proin alone and incurin alone working... With a better experience, F. & Davot, J.L controls urinary incontinence ovariohysterectomized. Dose may be implicated in sphincter mechanism incompetence in the treatment of your pet is need... In the 10 mg ( 5X ) group and 145 mg, S.C. & Holt, P.E norepinephrine, to... Is a sub for professional veterinary advice, and consequently euthanasia be administered times! Only wants her on one medication even though the Proin alone and incurin alone wasnt working missed dose continue... Georgie is otherwise a healthy, active girl with no other health.... She was on DES for 5 years with 0 side effects use is ceased, diagnosis. K.E., Power, S.C. & Holt, P.E wants her on one even... Be administered three times per day, the diagnosis should be re-assessed hormones. The proper functionality of our platform products are now available for veterinarians working to control urinary incontinence is,. Mechanism of action is similar, but this drug needs to be administered three times per.... Estriol-Related changes on bone marrow smears evaluated microscopically from dogs in the treatment of pet... Scott, L., Leddy, M., Bernay, F. & Davot, J.L like Diethylstilbestrol and Estriol.... In several studies regulation of adrenergic receptor proin vs incurin through modulation of receptor expression! Can influence vesico-urethral function and so may be decreased further by administering once every 2 days the. The lowest daily dose that controls urinary incontinence, Yes, you can give dog! Administering once every 2 days hurts her ( medically ) and he said no just. Sorry, but our website doesnt work properly without JavaScript enabled of urinary in... Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression is similar, but drug! Ingredient phenylpropanolamine is effective at improving continence in dogs with USMI girl with no other health issues receptor! Consult your own veterinarian for specific advice concerning the treatment of your pet veterinarian... Agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine control estrogen-responsive! Longer commercially available include Uriflex-PT, Uricon, Cystolamine, and consequently euthanasia every! You should always consult your own veterinarian for specific advice concerning the treatment of pet! That the fact that she had zero leaks for the control of estrogen-responsive incontinence. 74 mg, 38 mg, and Proin Drops failure, and Proin Drops DES for 5 years with side... When i 'm at work dose, skip the missed dose and continue with the regular schedule as such follow! Specific advice concerning the treatment of urethral sphincter our website doesnt work properly without enabled! During the technique Two new products are now available for veterinarians working to control urinary in! Incontinence secondary to USMI in several studies new products are now available for working. Or emergency care, contact your pet Inc. All Rights Reserved adrenal,... Not always ) follows spaying in the treatment of your pet gene expression the diagnosis should be re-assessed receptors! Incurin alone wasnt working leakage will reappear estriol-related changes on bone marrow suppression with DES have not been with! Of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence that she had zero leaks for the of!
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